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Korean J Hematol 2010; 45(2):
Published online June 30, 2010
https://doi.org/10.5045/kjh.2010.45.2.79
© The Korean Society of Hematology
Mutations in AML with a normal karyotype: NPM1 and FLT3 -ITD, ready to use as a key prognosticator?
Department of Internal Medicine, Division of Hematology, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
REFERENCES
- Fröhling, S, Schlenk, RF, Stolze, I, et al.
CEBPA mutations in younger adults with acute myeloid leukemia and normal cytogenetics: prognostic relevance and analysis of cooperating mutations. J Clin Oncol, 2004;22;624-633.
- Suzuki, T, Kiyoi, H, Ozeki, K, et al. Clinical characteristics and prognostic implications of
NPM1 mutations in acute myeloid leukemia. Blood, 2005;106;2854-2861.
- Schnittger, S, Schoch, C, Kern, W, et al. Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype. Blood, 2005;106;3733-3739.
- Suzuki, R, Onizuka, M, Kojima, M, et al. Prognostic significance of
FLT3 internal tandem duplication andNPM1 mutations in acute myeloid leukemia in an unselected patient population. Int J Hematol, 2007;86;422-428.
- Koh, Y, Park, J, Bae, EK, et al. Non-A type nucleophosmin 1 gene mutation predicts poor clinical outcome in de novo adult acute myeloid leukemia: differential clinical importance of
NPM1 mutation according to subtype. Int J Hematol, 2009;90;1-5.
- Döhner, K, Schlenk, RF, Habdank, M, et al. Mutant nucleophosmin (
NPM1 ) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations. Blood, 2005;106;3740-3746.
- Thiede, C, Koch, S, Creutzig, E, et al. Prevalence and prognostic impact of
NPM1 mutations in 1,485 adult patients with acute myeloid leukemia (AML). Blood, 2006;107;4011-4020.
- Kim, YK, Kim, HN, Lee, SR, et al. Prognostic significance of nucleophosmin mutations and FLT3 internal tandem duplication in adult patients with cytogenetically normal acute myeloid leukemia. Korean J Hematol, 2010;45;36-45.
- Schlenk, RF, Döhner, K. Impact of new prognostic markers in treatment decisions in acute myeloid leukemia. Curr Opin Hematol, 2009;16;98-104.
- Gale, RE, Green, C, Allen, C, et al. The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with
NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia. Blood, 2008;111;2776-2784.
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Editorial
Korean J Hematol 2010; 45(2): 79-80
Published online June 30, 2010 https://doi.org/10.5045/kjh.2010.45.2.79
Copyright © The Korean Society of Hematology.
Mutations in AML with a normal karyotype: NPM1 and FLT3 -ITD, ready to use as a key prognosticator?
Hee-Je Kim, M.D.
Department of Internal Medicine, Division of Hematology, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
References
- Fröhling, S, Schlenk, RF, Stolze, I, et al.
CEBPA mutations in younger adults with acute myeloid leukemia and normal cytogenetics: prognostic relevance and analysis of cooperating mutations. J Clin Oncol, 2004;22;624-633.
- Suzuki, T, Kiyoi, H, Ozeki, K, et al. Clinical characteristics and prognostic implications of
NPM1 mutations in acute myeloid leukemia. Blood, 2005;106;2854-2861.
- Schnittger, S, Schoch, C, Kern, W, et al. Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype. Blood, 2005;106;3733-3739.
- Suzuki, R, Onizuka, M, Kojima, M, et al. Prognostic significance of
FLT3 internal tandem duplication andNPM1 mutations in acute myeloid leukemia in an unselected patient population. Int J Hematol, 2007;86;422-428.
- Koh, Y, Park, J, Bae, EK, et al. Non-A type nucleophosmin 1 gene mutation predicts poor clinical outcome in de novo adult acute myeloid leukemia: differential clinical importance of
NPM1 mutation according to subtype. Int J Hematol, 2009;90;1-5.
- Döhner, K, Schlenk, RF, Habdank, M, et al. Mutant nucleophosmin (
NPM1 ) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations. Blood, 2005;106;3740-3746.
- Thiede, C, Koch, S, Creutzig, E, et al. Prevalence and prognostic impact of
NPM1 mutations in 1,485 adult patients with acute myeloid leukemia (AML). Blood, 2006;107;4011-4020.
- Kim, YK, Kim, HN, Lee, SR, et al. Prognostic significance of nucleophosmin mutations and FLT3 internal tandem duplication in adult patients with cytogenetically normal acute myeloid leukemia. Korean J Hematol, 2010;45;36-45.
- Schlenk, RF, Döhner, K. Impact of new prognostic markers in treatment decisions in acute myeloid leukemia. Curr Opin Hematol, 2009;16;98-104.
- Gale, RE, Green, C, Allen, C, et al. The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with
NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia. Blood, 2008;111;2776-2784.
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